The TERF Homology Domain (TRFH; InterPro: IPR013867) is an area that helps to promote homodimerization of TERF2 with itself. This results in the formation of a quaternary structure that is characteristic of this protein.
Various plants and Trypanosoma, organisms that are distantly related to metazoans and fungi, express proteins that contain a telobox at their C-terminus 1 and an N-terminal domain that is likely to fold into a TRFH structure (although its structure has not been solved yet).
TRF1 and TRF2 are key components of vertebrate telomeres. They bind to double-stranded telomeric DNA as homodimers. Dimerization involves the TRF homology (TRFH) domain, which also mediates interactions with other telomeric proteins.
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Aided by a novel crystal system of TRF1 TRFH , we characterised fragments binding in a hotspot at the TRF1:TIN2 interface; these will serve as a starting point for the structure-guided development of potent inhibitors of TRF1 protein:protein interactions to disrupt shelterin complex assembly.
RCSB PDB - 9HLU: Crystal structure of human TRF1 TRFH domain in complex ...